Fig. 5
From: A novel approach for breast cancer treatment: the multifaceted antitumor effects of rMeV-Hu191
Suppression of BC induced by rMeV-Hu191 in a nude mouse transplanted tumor model. (A) Changes in tumor volume over time in the mouse model. The blue line represents the mock-treated control group, while the red line represents the rMeV-Hu191 injection group. ****p < 0.0001. The black arrow indicates the time point of rMeV-Hu191 injection. (B) Kaplan–Meier survival curves comparing mice from the rMeV-Hu191 and mock-treated groups using a log-rank (Mantel-Cox) test. ****p < 0.0001. (C) Western blot analysis to assess the expression levels of MV-N and cleaved caspase 3 (c-caspase 3) in tissues from the rMeV-Hu191 injection group and the control group. The statistical analysis plots represent the mean ± standard error of three replicate experiments. *p < 0.05. (D) Immunofluorescence staining to determine MV-N expression in BC tissues with and without rMeV-Hu191 injection. Immunohistochemistry to analyze the expression of Ki67