Table 4 Interaction scores and networks between Type 2 diabetes mellitus (T2DM) and biomarkers
Chemical Name | Chemical ID | CAS RN | Gene Symbol | Gene ID | Interaction | Interaction Actions | Reference Count | Organism Count | |
|---|---|---|---|---|---|---|---|---|---|
bisphenol A | C006780 | ######## | CD82 | 3732 | bisphenol A results in decreased expression of CD82 mRNA | decreases^expression | 4 | 2 | |
Arsenic | D001151 | 7440–38-2 | CDKN1A | 1026 | Arsenic results in increased expression of CDKN1A mRNA | increases^expression | 2 | 1 | |
Cadmium | D002104 | 7440–43-9 | CDKN1A | 1026 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKN1A mRNA | increases^expression | 2 | 1 | |
Dibutyl Phthalate | D003993 | 84–74-2 | CDKN1A | 1026 | Dibutyl Phthalate results in increased expression of CDKN1A mRNA | increases^expression | 2 | 2 | |
Drugs, Chinese Herbal | D004365 | CDKN1A | 1026 | Drugs, Chinese Herbal results in increased expression of CDKN1A mRNA | increases^expression | 2 | 1 | ||
Silver | D012834 | 7440–22-4 | CDKN1A | 1026 | Silver analog results in increased expression of CDKN1A mRNA | increases^expression | 2 | 1 | |
titanium dioxide | C009495 | 13,463–67-7 | CDKN1A | 1026 | titanium dioxide results in decreased expression of CDKN1A mRNA | decreases^expression | 2 | 2 | |
Dibutyl Phthalate | D003993 | 84–74-2 | MIOX | 55,586 | Dibutyl Phthalate results in decreased expression of MIOX mRNA | decreases^expression | 2 | 1 | |
perfluorooctanoic acid | C023036 | 335–67-1 | MIOX | 55,586 | perfluorooctanoic acid results in increased expression of MIOX mRNA | increases^expression | 2 | 2 | |
alpha-Tocopherol | D024502 | ######## | CDKN1A | 1026 | alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | |
Ascorbic Acid | D001205 | 50–81-7 | CDKN1A | 1026 | [Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | |
bis(4-hydroxyphenyl)sulfone | C543008 | ######## | CDKN1A | 1026 | bis(4-hydroxyphenyl)sulfone results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | |
bisphenol A | C006780 | ######## | CDKN1A | 1026 | [bisphenol A co-treated with cylindrospermopsin] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Chromium | D002857 | 7440–47-3 | CDKN1A | 1026 | Chromium results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | |
cinnamaldehyde | C012843 | CDKN1A | 1026 | cinnamaldehyde results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | ||
Copper | D003300 | 7440–50-8 | CDKN1A | 1026 | [Chelating Agents binds to Copper] which results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
coumarin | C030123 | 91–64-5 | CDKN1A | 1026 | coumarin analog results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Curcumin | D003474 | 458–37-7 | CDKN1A | 1026 | [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Dietary Fats | D004041 | CDKN1A | 1026 | [Dietary Fats co-treated with Choline deficiency] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | ||
Diethylnitrosamine | D004052 | 55–18-5 | CDKN1A | 1026 | AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A mRNA] | decreases^expression | 1 | 1 | |
epigallocatechin gallate | C045651 | 989–51-5 | CDKN1A | 1026 | [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Folic Acid | D005492 | 59–30-3 | CDKN1A | 1026 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | |
Genistein | D019833 | 446–72-0 | CDKN1A | 1026 | [Calcitriol co-treated with Genistein] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
ginsenoside Re | C049864 | 52,286–59-6 | CDKN1A | 1026 | ginsenoside Re results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Gliclazide | D005907 | 21,187–98-4 | CDKN1A | 1026 | Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | |
Glucose | D005947 | 50–99-7 | CDKN1A | 1026 | [Glucose co-treated with Deferoxamine] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Iron | D007501 | 7439–89-6 | CDKN1A | 1026 | [Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Manganese | D008345 | 7439–96-5 | CDKN1A | 1026 | Manganese deficiency results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Metformin | D008687 | 657–24-9 | CDKN1A | 1026 | Metformin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA] | decreases^expression | 1 | 1 | |
Niacinamide | D009536 | 98–92-0 | CDKN1A | 1026 | [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CDKN1A mRNA] | decreases^expression | 1 | 1 | |
Nickel | D009532 | 7440–02-0 | CDKN1A | 1026 | [Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Nicotine | D009538 | CDKN1A | 1026 | Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | ||
Particulate Matter | D052638 | CDKN1A | 1026 | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Particulate Matter results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | ||
perfluorooctane sulfonic acid | C076994 | 1763–23-1 | CDKN1A | 1026 | perfluorooctane sulfonic acid results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | |
perfluorooctanoic acid | C023036 | 335–67-1 | CDKN1A | 1026 | perfluorooctanoic acid inhibits the reaction [Calcitriol results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | |
perfluoroundecanoic acid | C586085 | CDKN1A | 1026 | perfluoroundecanoic acid results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | ||
Pesticides | D010575 | CDKN1A | 1026 | Pesticides results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | ||
Plant Extracts | D010936 | CDKN1A | 1026 | [Plant Extracts co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | ||
Polychlorinated Biphenyls | D011078 | CDKN1A | 1026 | Polychlorinated Biphenyls analog results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | ||
Resveratrol | D000077185 | CDKN1A | 1026 | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | ||
Rosiglitazone | D000077154 | CDKN1A | 1026 | Rosiglitazone results in decreased expression of CDKN1A mRNA | decreases^expression | 1 | 1 | ||
Streptozocin | D013311 | 18,883–66-4 | CDKN1A | 1026 | 2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | |
TAK-875 | C557331 | CDKN1A | 1026 | TAK-875 results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | ||
Troglitazone | D000077288 | 97,322–87-7 | CDKN1A | 1026 | [Troglitazone co-treated with IFNG protein] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
Vehicle Emissions | D001335 | CDKN1A | 1026 | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Vehicle Emissions results in increased expression of CDKN1A mRNA] | increases^expression | 1 | 1 | ||
Zinc | D015032 | 7440–66-6 | CDKN1A | 1026 | [PCI 5002 co-treated with Zinc] results in increased expression of CDKN1A mRNA | increases^expression | 1 | 1 | |
bisphenol A | C006780 | ######## | MIOX | 55,586 | bisphenol A results in decreased expression of MIOX mRNA | decreases^expression | 1 | 1 | |
Diethylnitrosamine | D004052 | 55–18-5 | MIOX | 55,586 | Diethylnitrosamine results in increased expression of MIOX mRNA | increases^expression | 1 | 1 | |
Folic Acid | D005492 | 59–30-3 | MIOX | 55,586 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIOX mRNA | increases^expression | 1 | 1 | |
Plant Extracts | D010936 | MIOX | 55,586 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of MIOX mRNA | decreases^expression | 1 | 1 | ||
Resveratrol | D000077185 | MIOX | 55,586 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of MIOX mRNA | decreases^expression | 1 | 1 | ||
Rosiglitazone | D000077154 | MIOX | 55,586 | Rosiglitazone results in increased expression of MIOX mRNA | increases^expression | 1 | 1 | ||
titanium dioxide | C009495 | 13,463–67-7 | MIOX | 55,586 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of MIOX mRNA | decreases^expression | 1 | 1 | |
Troglitazone | D000077288 | 97,322–87-7 | MIOX | 55,586 | Troglitazone results in increased expression of MIOX mRNA | increases^expression | 1 | 1 | |
Air Pollutants | D000393 | MYCN | 4613 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | ||
bisphenol A | C006780 | ######## | MYCN | 4613 | bisphenol A results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | |
Copper | D003300 | 7440–50-8 | MYCN | 4613 | [Copper co-treated with Chlorpyrifos] results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | |
Dietary Fats | D004041 | MYCN | 4613 | Dietary Fats results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | ||
Diethylnitrosamine | D004052 | 55–18-5 | MYCN | 4613 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | |
Folic Acid | D005492 | 59–30-3 | MYCN | 4613 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MYCN mRNA | decreases^expression | 1 | 1 | |
Genistein | D019833 | 446–72-0 | MYCN | 4613 | Genistein results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | |
Pantothenic Acid | D010205 | 79–83-4 | MYCN | 4613 | Pantothenic Acid results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | |
perfluoroundecanoic acid | C586085 | MYCN | 4613 | perfluoroundecanoic acid results in increased expression of MYCN mRNA | increases^expression | 1 | 1 | ||
Resveratrol | D000077185 | MYCN | 4613 | Resveratrol inhibits the reaction [Dietary Fats results in increased expression of MYCN mRNA] | increases^expression | 1 | 1 | ||
Silver | D012834 | 7440–22-4 | MYCN | 4613 | Silver results in decreased expression of MYCN mRNA | decreases^expression | 1 | 1 | |
titanium dioxide | C009495 | 13,463–67-7 | MYCN | 4613 | titanium dioxide results in decreased expression of MYCN mRNA | decreases^expression | 1 | 1 | |
Ascorbic Acid | D001205 | 50–81-7 | CD82 | 3732 | Ascorbic Acid results in increased expression of CD82 mRNA | increases^expression | 1 | 1 | |
bis(4-hydroxyphenyl)sulfone | C543008 | ######## | CD82 | 3732 | bis(4-hydroxyphenyl)sulfone results in increased expression of CD82 mRNA | increases^expression | 1 | 1 | |
Dibutyl Phthalate | D003993 | 84–74-2 | CD82 | 3732 | Dibutyl Phthalate results in increased expression of CD82 mRNA | increases^expression | 1 | 1 | |
Dietary Fats | D004041 | CD82 | 3732 | Dietary Fats results in decreased expression of CD82 mRNA | decreases^expression | 1 | 1 | ||
Genistein | D019833 | 446–72-0 | CD82 | 3732 | Genistein results in increased expression of CD82 mRNA | increases^expression | 1 | 1 | |
Glucose | D005947 | 50–99-7 | CD82 | 3732 | [INS protein co-treated with Glucose] results in increased expression of CD82 mRNA | increases^expression | 1 | 0 | |
Lead | D007854 | 7439–92-1 | CD82 | 3732 | Lead results in decreased expression of CD82 mRNA | decreases^expression | 1 | 1 | |
Particulate Matter | D052638 | CD82 | 3732 | Particulate Matter results in decreased expression of CD82 mRNA | decreases^expression | 1 | 1 | ||
perfluorooctane sulfonic acid | C076994 | 1763–23-1 | CD82 | 3732 | perfluorooctane sulfonic acid results in decreased expression of CD82 mRNA | decreases^expression | 1 | 1 | |
perfluorooctanoic acid | C023036 | 335–67-1 | CD82 | 3732 | perfluorooctanoic acid results in decreased expression of CD82 mRNA | decreases^expression | 1 | 1 | |
Vehicle Emissions | D001335 | CD82 | 3732 | [Allergens co-treated with Vehicle Emissions] results in increased expression of CD82 mRNA | increases^expression | 1 | 1 | ||