Fig. 9

Regulatory and diagnostic significance of miRNAs targeting hub genes in esophageal squamous cell carcinoma (ESCA). (A) Predicted miRNA-hub gene interactions identified using TargetScan. (B) RT-qPCR analysis of hsa-miR-29b-3p, hsa-miR-29a-3p, hsa-miR-4458, and hsa-miR-325-3p expression levels in ESCA and normal control cells. (C) ROC curve analysis of hsa-miR-29b-3p, hsa-miR-29a-3p, hsa-miR-4458, and hsa-miR-325-3p. P*** < 0.001