Fig. 5

Identification of diagnostic markers. A Three genes including APLNR, HLA-DPA1 and AP1S2 were obtained using the least absolute shrinkage and selection operator [27]. B Sixteen genes corresponding to the EM were obtained by the boruta algorithm. C Support vector machine-recursive feature elimination (SVM-RFE) algorithm to screen diagnostic markers. D Ten genes were defined as key genes by random forest. E Venn diagram showing the intersection among diagnostic markers between the four algorithms