Fig. 5

SNHG16 co-regulates cell physiological functions with miR-432-5p. A: Transfection of SNHG16 leads to a significant decrease in the level of miR-432-5p, while its mimics increase its expression level; B: Increasing the level of SNHG16 had no significant effect on the apoptosis rate, but increasing the level of miR-432-5p resulted in a significant increase in the apoptosis rate; C: The cell proliferation capacity after increasing the level of SNHG16 was increased but not significantly. Increasing the level of miR-432-5p resulted in a significant decrease in the proliferative capacity of the cells; D: After increasing the level of SNHG16, the level of miR-432-5p was decreased and the level of bone-related synthetic proteins (Col-1, RUNX2, OCN) was significantly increased. However, after increasing the level of miR-432-5p, the expression levels of Col-1, RUNX2, OCN were significantly decreased (*** P < 0.001 vs. pcDNA3.1 NC, &&& P < 0.001 vs. pcDNA3.1 SNHG16 + mimic NC)