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Table 5 Comparative analysis of Nrf2 and HO-1 gene copy numbers in skeletal muscles of five groups of mice

From: Regulation of the Nrf2/HO-1 pathway in chronic obstructive pulmonary disease-induced muscle atrophy using Jinshui Liujian decoction and Bajitian pills: insights from network pharmacology and animal models

Group

n

Nrf2

HO-1

Control

8

1.000 ± 0.024

1.008 ± 0.020

COPD model

8

0.445 ± 0.138

0.795 ± 0.110

TCM

8

0.734 ± 0.066*

1.177 ± 0.145*

WM

8

0.662 ± 0.110#

1.262 ± 0.181#

TCM-WM combination

8

0.852 ± 0.071@

1.416 ± 0.156@

f value

 

42.03

25.21

P value

 

< 0.001

< 0.001

  1. Note: For Nrf2 gene copy numbers, compared with the control group, P < 0.001 for all four model groups; compared with the model group, P < 0.05 for the other three groups; compared with the WM group (#), *P = 0.543, @P = 0.011
  2. For HO-1 gene copy numbers, compared with the control group, P < 0.05 for all four model groups; compared with the model group, P < 0.001 for the other three groups; compared with the WM group (#), *P = 0.215, @P = 0.029
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Hereditas

ISSN: 1601-5223

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